Journal: Heliyon
Article Title: Atractylenolide III ameliorated reflux esophagitis via PI3K/AKT/NF-κB/iNOS pathway in rats
doi: 10.1016/j.heliyon.2023.e21224
Figure Lengend Snippet: ATL III inhibits PI3K/AKT/NF-κB/iNOS pathway. A) Images show the esophagus of rats after treatment with a) sham group, b) RE group, c) RE+2.4 mg/kg of ATL III, d) RE+2.4 mg/kg of ATL III +10 mg/kg of 740 Y–P. B) H&E stained images of the sectioned esophagus tissues of rats after treatment with a) sham group, b) RE group, c) RE+2.4 mg/kg ATL III, d) RE+2.4 mg/kg of ATL III +10 mg/kg of 740 Y–P. Arrow marker: lymphocyte infiltration. C) The graph represents the esophageal mucosal injury score after treatment with ATL III +10 mg/kg of 740 Y–P in RE rats. D) The graph signifies the gastric content pH after treatment with ATL III +10 mg/kg of 740 Y–P in RE rats. E) The image shows the ROS levels after treatment with ATL III +10 mg/kg of 740 Y–P in RE rats. F) The image shows the TBARS levels after treatment with ATL III +10 mg/kg of 740 Y–P in RE rats. G) The image shows the expression levels of various inflammatory indicators (TNF-α, IL-8, IL-6, and IL-1β) after treatment with ATL III + 10 mg/kg of 740 Y–P in RE rats. ** indicates P < 0.01 and *** represents P < 0.001 vs. RE. & presents P < 0.05 and &&& signifies P < 0.001 vs. RE + 2.4 mg/kg ATL III.
Article Snippet: ATL III and 740 Y–P were obtained from Abmole Bioscience Inc. (Shanghai, China).
Techniques: Staining, Marker, Expressing